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KMID : 0383820100690060450
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Tuberculosis and Respiratory Diseases
2010 Volume.69 No. 6 p.450 ~ p.455
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Usefulness of Serum Cortisol in Assessment for the Severity of Community-Acquired Pneumonia
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Yoon Kyung-Hwa
Kim Yeon-Jae
Kim Mi-Young
Kim Eun-Young
Bae Myoung-Nam
Bae Sang-Mook
Kim Min-Su
Park Hun-Pyo
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Abstract
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Background : High cortisol levels are frequently observed in patients with severe infections are of prognostic value in sepsis. The aim of this study was to evaluate the clinical usefulness of serum cortisol in assessment for the severity of community-acquired pneumonia (CAP).
Materials and Methods : This study analyzed the results of 52 CAP subjects admitted in Changwon Fatima Hospital between July 2008 to May 2010. Total serum cortisol, infection markers such as C-reactive protein (CRP), procalcitonin (PCT) and CURB (Confusion, Uremia, Respiratory rate, Blood pressure)-65 were examined retrospectively.
Results : In clinically unstable subjects on admission day 4, baseline serum cortisol, CURB-65, and CRP were elevated significantly compared to those of stable subjects. Area under curve (AUC) of cortisol, CRP, and CURB-65 from ROC curves were 0.847, 0.783, and 0.724 respectively. In the subjects with serum cortisol ≥22.82 μg/dL, CRP, PCT, CURB-65 score, and mortality were significantly elevated.
Conclusion : These findings suggest that measurement of serum cortisol in early stage may provide helpful information in the assessment of CAP severity.
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KEYWORD
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Community acquired infections, Pneumonia, Cortisol, Severity of Illness Index, CURB-65
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